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. 2021 Feb 10;8(7):2003572. doi: 10.1002/advs.202003572

Figure 14.

Figure 14

Schematic depiction of chemotaxis‐driven delivery of NPNs to eradicate tumors. a) Procedures for neutrophils to capture pathogens. b) Fabrication process of NPNs. c) Chemical structures of PEG‐b‐PLGA and PBIBDF‐BT. d) Insufficient penetration of laser leads to heterogeneous heat distribution within tumor mass, resulting in tumor recurrence. e) Treatment‐induced tumor cell death led to an inflammatory TME and induced the production of cytokines and chemokines. #1a The increased production of G‐CSF and GM‐CSF increased the number of neutrophils from bone marrow. #1b The increased production of CXCL1 and MIP‐2 visualized the inflamed tumor to immune system. #2 Neutrophils get into the circulating blood and encountered NPNs. #3 Neutrophils sensed NPNs with PRRs and subsequently engulfed NPNs. #4 In response to the gradient of chemokine, NPNs‐loaded neutrophils were recruited to the tumor site. #5 Released NPNs destroy tumor cells coupled with the NETs formation. Reproduced with permission.[ 94 ] Copyright 2020, Springer Nature.