Table 2.
SNCA variants associated with REM Sleep Behavior Disorder.
| SNP | rs10005233 | rs11732740 |
|---|---|---|
| Alleles, effect/reference | T/C | G/A |
| GRCh37/hg19 base position | 4:90743331 | 4:90423029 |
| Analysis, n cases/controls = 1,031/5,864 | ||
| Effect allele frequency cases/controls | 0.58 / 0.49 | 0.21 / 0.17 |
| Phred-Scaled CADD | 4.71 | 4.67 |
| Stepwise Conditional Analysis | ||
| Conditioned on | NA | rs10005233 |
| OR (95% CI) | 1.43 (1.27 – 1.62) | 1.32 (1.13 – 1.53) |
| p | 1.11E-08 | 0.00047 |
| Combined Model | ||
| OR (95% CI) | 1.42 (1.26–1.61) | 1.32 (1.13–1.53) |
| p | 2.73E-08 | 0.0005 |
SNP: single nucleotide polymorphism. CADD: combined annotation dependent depletion. OR: odds ratio. CI: confidence interval. NA: not applicable.