Table 3.
Univariable and multivariable Logistic Regression for poor outcome
| Missing values (%) | OR (univariable) | OR (multivariable) | |
|---|---|---|---|
| Hyponatremia | 0 | 2.73 (1.59–4.70, p < 0.001) | 2.77 (1.26–6.15, p = 0.011) |
| Age | 0 | 0.99 (0.97–1.00, p = 0.145) | 1.01 (0.99–1.04, p = 0.356) |
| Male | 0 | 1.70 (1.00–2.94, p = 0.051) | 1.18 (0.53–2.69, p = 0.687) |
| Diabetes | 0 | 1.41 (0.71–2.70, p = 0.312) | 1.74 (0.67–4.41, p = 0.244) |
| Temperature | 12 | 2.55 (1.79–3.76, p < 0.001) | N/A |
| Temperature > 38.5 °C | 3.39 (1.83–6.56, p < 0.001) | 2.67 (1.13–6.69, p = 0.029) | |
| Oxygen therapy | |||
| None | 4 | ||
| ≤ 6 l/min | 1.68 (0.88–3.18, p = 0.112) | 1.54 (0.67–3.54, p = 0.309) | |
| > 6 l/min | 19.86 (7.87–57.76, p < 0.001) | 16.90 (5.56–58.97, p < 0.001) | |
| Creatinine* | 0.3 | 1.00 (1.00–1.01, p = 0.312) | 0.96 (0.34–2.60, p = 0.939) |
| ALT* | 19 | 1.01 (1.00–1.01, p = 0.036) | 1.54 (0.67–3.54, p = 0.309) |
| Lymphocyte count* | 13 | 1.05 (0.98–1.14, p = 0.208) | 1.51 (0.90–2.58, p = 0.121) |
| Time between onset of symptoms and admission | 0 | 1.00 (0.95–1.05, p = 0.944) | |
| Obesity | 26 | 2.17 (1.08–4.32, p = 0.028) | |
| Congestive heart failure | 0 | 0.81 (0.31–1.89, p = 0.651) | |
| Coronary artery disease | 0 | 0.77 (0.35–1.60, p = 0.508) | |
| Cirrhosis | 0 | 1.37 (0.06–14.50, p = 0.798) | |
| Active neoplasia | 0 | 0.77 (0.21–2.22, p = 0.651) | |
| Current smoker | 0 | 1.62 (0.63–3.96, p = 0.296) | |
| Diarrhea | 2.1 | 1.06 (0.59–1.86, p = 0.841) | |
| Vomiting | 2.1 | 1.33 (0.52–3.10, p = 0.529) | |
| Agueusia | 33.0 | 0.42 (0.15–1.01, p = 0.070) | |
| Anosmia | 33.7 | 0.54 (0.19–1.30, p = 0.195) | |
| Systolic blood pressure | 4.1 | 1.01 (0.99–1.02, p = 0.258) | |
| Diastolic blood pressure | 4.5 | 1.01 (0.98–1.03, p = 0.519) | |
| Respiratory rate | 21 | 1.12 (1.07–1.18, p < 0.001) | |
| Neurological involvement | 2.8 | 1.64 (0.79–3.31, p = 0.172) | |
| CT-scan | 57.7 | ||
| < 30% lesions | |||
| 30–50% lesions | 1.89 (0.66–5.94, p = 0.246) | ||
| > 50% lesions | 17.25 (5.64–61.06, p < 0.001) | ||
| AST | 19.2 | 1.01 (1.00–1.01, p = 0.023) | |
| Fibrinogen | 49.8 | 1.39 (1.13–1.72, p = 0.002) | |
| Troponin | 39.9 | 1.00 (1.00–1.01, p = 0.222) | |
| Creatine Kinase | 44.3 | 1.00 (1.00–1.00, p = 0.660) | |
| C-Reactive Protein | 25.1 | 1.01 (1.01–1.02, p < 0.001) |
Odds-Ratios (OR) were calculated by univariable and multivariable not weighted logistic regression models. Subjective symptoms and variables with an excess of missing values (i.e. > 20%) were withdrawn from the multivariable analysis. Due to the strong correlation with oxygen flow rate and the number of missing values, respiratory rate was not included in the multivariate analysis
N/A not applicable
*Creatinine, lymphocyte count and ALT were included in the model as natural logarithmic transformation