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. 2021 Mar 31;45(5):87. doi: 10.3892/or.2021.8038

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Copyright: © Amin et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Inhibition of in vivo tumor growth by the combination of EGCG and resveratrol in nude mice. (A) Four groups of animals were orally gavaged with vehicle control, EGCG, resveratrol, or their combination as described in Materials and methods. Growth curves were obtained for xenografted tumors. Tu212 tumor growth was significantly inhibited only in the combination group as compared with the control (P=0.026). Other comparisons were insignificant (P>0.05). (B) Tumors were weighed at the end of the experiment. Similar to tumor volumes, tumor weights were also significantly inhibited only in the combination group as compared with the control. (C) Images of tumor-bearing mice at the end of the study. (D) Ki67 and TUNEL expression detected in xenograft tissues by immunohistochemical analysis. Representative images are presented from each group (magnification, ×200). (E and F) Quantification of Ki67 and TUNEL staining. *P<0.05 indicates a statistically significant difference. EGCG, epigallocatechin gallate.