Figure 5.

Inhibition of AKT-mTOR signaling is required for apoptosis induced by the combination of EGCG and resveratrol. (A) MDA686TU cells were transduced with constitutively active AKT and expression of p-AKT, p-S6 and p-4E-BP1 was examined in whole cell lysates. (B) Non-transduced and transduced cells were treated with the combination of EGCG and resveratrol and apoptosis was measured after 72 h. Averages of triplicate treatments were graphed with standard deviations as error bars. EGCG, epigallocatechin gallate; p, phosphorylated; NT, no treatment.