. 2021 Apr 6;4(4):e214475. doi: 10.1001/jamanetworkopen.2021.4475

Table 2. Clinical Information of Patients With KD During April to May, in 2015 to 2019 and 2020.

Characteristic	Patients, No. (%)		P value
Characteristic	2020 (n = 36)	2015-2019 (n = 248)	P value
Age at onset, median (IQR), mo	22 (11-38)	29 (13-48)	.11^a
Sex
Female	14 (38.9)	109 (44.0)	.60^b
Male	22 (61.1)	139 (56.0)	.60^b
Day of illness at diagnosis, mean (SD)	4.9 (2.2)	5.0 (2.0)	.73^c
Laboratory values just before treatment
White blood cell count, median (IQR), cells/μL	12 800 (9 600-15 600)	14 800 (11 700-19 400)	.01^a
Neutrophil percentage, median (IQR), %^d	69.3 (50.4-76.0)	72.3 (58.9-84.8)	.04^a
Hemoglobin, median (IQR), g/dL	11.4 (10.8-12.2)	11.5 (10.8-12.2)	.75^a
Platelet, median (IQR), ×10³/μL	326 (259-403)	331 (279-411)	.45^a
Aspartate aminotransferase, median (IQR), U/L	38 (28-105)	33 (26-64)	.13^a
Alanine aminotransferase, median (IQR), U/L	27 (13-86)	18 (12-73)	.25^a
Serum sodium, median (IQR), mEq/L	135 (134-137)	135 (134-137)	.74^a
Total bilirubin, median (IQR), mg/dL^e	0.60 (0.40-1.05)	0.54 (0.40-0.89)	.55^a
C-reactive protein, median (IQR), mg/dL	7.1 (3.8-12.7)	7.4 (4.4-11.9)	.84^a
Risk score^f
Kobayashi score, median (IQR)	3 (1-5)	3 (1-5)	.86^a
Egami score, median (IQR)	2 (1-3)	2 (1-2)	.45^a
Osaka score, median (IQR)	1 (0-1)	1 (0-1)	.67^a
Final diagnosis
Incomplete KD	3 (8.3)	15 (6.0)	.49^b
IVIG resistant	3 (8.3)	69 (27.8)	.01^b
Cardiac complications
Coronary artery dilatation before IVIG^g	3 (8.3)	14 (5.6)	.46^b
Cardiac complications at 4 weeks after onset	2 (5.6)	6 (2.4)	.27^b

Abbreviations: IQR, interquartile range; IVIG, intravenous immunoglobulin; KD, Kawasaki disease.

SI conversion factors: To convert alanine aminotransferase to microkatals per liter, multiply by 0.0167; aspartate aminotransferase to microkatals per liter, multiply by 0.0167; C-reactive protein to milligrams per liter, multiply by 10.0; hemoglobin to grams per liter, multiply by 10.0; neutrophil percentage to proportion of 1.0, multiply by 0.01; platelets to ×10⁹ cells per liter, multiply by 1.0; serum sodium to millimoles per liter, multiply by 1.0; total bilirubin to micromoles per liter, multiply by 17.104; white blood cell count to ×10⁹ cells per liter, multiply by 0.001.

^{^a}

Calculated with Mann-Whitney U test.

^{^b}

Calculated with Fisher exact test.

^{^c}

Calculated with t test.

^{^d}

Data on neutrophil percentage were missing for 2 patients.

^{^e}

Data on total bilirubin were missing for 7 patients.

^{^f}

The Kobayashi score consists of age (1 point), day of illness at diagnosis (2 points), neutrophil percentage (2 points), platelet count (1 point), aspartate aminotransferase level (2 points), serum sodium level (2 points), and C-reactive protein level (1 point) with a score of 5 or higher indicating IVIG resistance. The Egami score consists of age (1 point), day of illness (1 point), alanine aminotransferase level (2 points), platelet count (1 point), and C-reactive protein level (1 point), with a score of 3 or higher indicating IVIG resistance. The Osaka score consists of aspartate aminotransferase level (1 point), total bilirubin level (1 point), and C-reactive protein level (1 point), with a score of 2 or higher indicating IVIG resistance.

^{^g}

One patient did not undergo an echocardiogram before treatment.