Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
(A) Structure of the bivalent degrader, MZ1, which contains a bromo- and extra-terminal domain targeting ligand (JQ1) and a ligand for VHL. (B) MZ1 achieves selective degradation of BRD4 even though JQ1 is about equipotent for BRD2, BRD3 and BRD4.
VHL: von Hippel-Lindau.
