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. 2021 Apr 5;218(5):e20202191. doi: 10.1084/jem.20202191

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© 2021 Bechara et al.

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Figure 1. — Overview of IL-17–mediated metabolic regulation. IL-17–driven metabolic pathways deliver vital signals for tissue homeostasis. In parallel, metabolic regulation underlies many IL-17–driven pathologies. Cellular and organismal metabolic homeostasis cannot be sustained without appropriate temporally and spatially regulated IL-17 signaling, at the risk of damage to tissues with critical metabolic functions.