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. 2021 Apr 5;218(5):e20202191. doi: 10.1084/jem.20202191

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© 2021 Bechara et al.

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Figure 3. — IL-17–mediated metabolic regulation in adipose tissue. The IL-17 pathway exerts an antiadipogenic role by suppressing adipocyte differentiation through decreased expression of proadipogenic TFs. IL-17A promotes thermogenesis in BAT by supporting a UCP1-dependent thermogenic response. Moreover, IL-17 synergizes with TNF-α to induce IL-33 by stromal adipose cells, leading to T reg cell expansion. IL-17F is reported to trigger sympathetic innervation and norepinephrine (NE) release.