Table 1. IL-17–driven metabolic pathways in health and disease.

IL-17–mediated metabolic regulation during homeostasis
IL-17 target cells	Metabolic regulation	Cellular outcome	Organismal outcome	References
Epithelial cells/Mesenchymal cells	Unknown	Proliferation	Tissue repair and wound healing	Lee et al. (2015), Song et al. (2015), MacLeod et al. (2013), Chen et al. (2019), Floudas et al. (2017)
Adipocytes	Decreased expression of proadipogenic TFs	Suppressed differentiation of adipocytes	Decreased adipose tissue mass accumulation	Ahmed and Gaffen (2013)
	Decreased insulin-mediated glucose uptake in vitro	Unknown	Unknown	Zúñiga et al. (2010)
	Increased expression of thermogenic genes	Enhanced metabolic respiration via uncoupled oxidative phosphorylation	Thermogenesis	Kohlgruber et al. (2018), Papotto and Silva-Santos (2018)
Stromal adipose cells	Unknown	IL-33 production	Insulin sensitivity	Kohlgruber et al. (2018), Papotto and Silva-Santos (2018)
IL-17–mediated metabolic regulation during disease
IL-17 target cells	Metabolic regulation	Cellular outcome	Organismal outcome	References
Epithelial cells/Mesenchymal cells	Unknown	ECM production	Fibrosis	Okamoto et al. (2012), Madhur et al. (2010), Wilson et al. (2010), Wu et al. (2014), Mi et al. (2011)
	Increased glycolysis	Proliferation	Tumorigenesis	Terzić et al. (2010), Straus (2013)
Keratinocytes	Reprogramming of urea cycle	Proinflammatory gene expression	Psoriasis	Lou et al. (2020), Bandyopadhyay and Larregina (2020)
	Increased cholesterol uptake	Proinflammatory gene expression	Psoriasis	Varshney et al. (2016)
SFs	Decreased expression of oxidative phosphorylation genes	Cell survival	RA	Kim et al. (2017)
	Increased expression of amino acid transporter 1	Increased cell migratory capacity	RA	Yu et al. (2018)
FRCs	Increased glycolysis/Increased FAO	Cell survival and proinflammatory genes expression	EAE/Colitis	Majumder et al. (2019)

The metabolism-modulating activities of IL-17 are context dependent and may vary on the basis of its target cells.