Correction to: Acta Neuropathologica (2020) 139:1045–1070 10.1007/s00401-020-02148-4
In the original publication, Table 1 column heads are incorrectly formatted and aligned. The corrected Table 1 is given here.
Table 1.
Clinical and molecular characteristics of ten Iberian FTLD-MAPT-P301L cases
| Case | Sex | Age at death | Duration (years) | Signs at onset | Initial diagnosis | MAPT haplotype | ApoE | PMI (h) | Frontal cortex | Dentate nucleus of the cerebellum | Hippocampus | Parahippocampus | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Neuronal loss/AT8 | D/N | Neuronal loss/AT8 | D/N | Neuronal loss/AT8 | Neuronal loss/AT8 | |||||||||
| 1 | M | 52 | 6 | Behavior | bvFTD | H1/H1 | e3/e3 | 13.5 | ++/+++ | 3.6 ± 0.2 | −/− | 1.0 ± 0.0 | −/+++ | ++/+++ |
| 2 | M | 58 | 5 | Behavior | bvFTD | H1/H1 | e3/e4 | 13 | +++/+++ | 4.1 ± 0.1 | −/+ | 1.0 ± 0.1 | −/+++ | ++/+++ |
| 8 | M | 58 | 7 | Behavior | bvFTD | H1/H1 | e3/e4 | 10 | +++/++ | 4.9 ± 0.3 | −/+ | 1.0 ± 0.1 | −/+++ | +++/+++ |
| 7a | F | 61 | 5 | Behavior | bvFTD | H1/H1 | e3/e3 | 14.8 | ++/+++ | 4.6 ± 0.1 | −/+ | 1.7 ± 0.1 | −/+++ | ++/++ |
| 4 | M | 72 | 13 | Memory | AD | H1/H1 | e3/e3 | 5.8 | +++/+++ | 3.7 ± 0.3 | −/+ | 1.0 ± 0.1 | +/+++ | +++/+++ |
| 6 | M | 53 | 7 | Memory | AD | H1/H1 | e3/e3 | 16.7 | +++/+++ | 12.6 ± 1.2 | −/− | 1.2 ± 0.1 | −/+++ | +++/+++ |
| 9 | M | 75 | 7 | Behavior | AD | H1/H2 | e3/e3 | 5.9 | ++/+++ | 5.9 ± 0.1 | −/− | 3.1 ± 0.1 | −/+++ | ++/+++ |
| 5 | F | 63 | 4 | Language | AD or svPPA | H1/H2 | e3/e3 | 7.3 | ++/++ | 4.6 ± 0.1 | −/+ | 1.2 ± 0.2 | −/+++ | ++/+++ |
| 3 | M | 56 | 10 | Language | svPPA | H1/H1 | e3/e3 | 6.3 | +++/+++ | 10.3 ± 0.9 | −/+ | 1.0 ± 0.1 | −/+++ | +++/+++ |
| 12 | M | 49 | 6 | Language | svPPA | H1/H1 | e3/e3 | 7.4 | ++/+++ | 8.2 ± 0.5 | −/+ | 3.3 ± 0.1 | ND | ND |
Table after 34, arranged by initial clinical diagnosis: BvFTD behavioral variant of FTD, SvPPA semantic variant of primary progressive aphasia, AD Alzheimer disease, PMI post mortem interval. All presented cases were FUS negative, TDP43 negative. D/N denatured/native ratio in CDI assay, ± standard deviation
Age at onset was 51.3 ± 4, 60.7 ± 11.9, 50 ± 7 for bv, AD, sv respectively. Age at death was 57.3 ± 3.8, 66.7 ± 11.9 and 56 ± 7 for bv, AD, sv respectively. None of the differences in ages are significant
aAlso feature globular glial tauopathy affecting oligodendrocytes
Footnotes
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Contributor Information
Jiri G. Safar, Email: jiri.safar@case.edu
David Westaway, Email: david.westaway@ualberta.ca.