Table 6.
Targets conserved in human cells not previous associated with Torin1-regulated signalling. A list of human orthologues of the new targets of Torin1 signalling. GO-term mapping indicated the biological process regulated by the individual proteins.
| novel Torin1-regulated proteins—human orthologues |
|---|
| RNA metabolic processes (including: translation, splicing, ribosomal protein, RNA stability) |
| CSTF2T POLR3B RPAP1 RPS23 TARS1 TRNAU1AP UPF2 ZCCHC7 |
| vesicle-mediated transport |
| ARFGAP1 EPN3 RIC1 SEC31A UNC13A |
| cytoskeleton organization |
| CAPZA2 NEBL PI4KA PLEK2 KIAA1217 |
| autophagy |
| WDFY4 |
| protein folding |
| AHSA1 |
| metal ion homeostasis |
| PAQR3 |
| mitochondrial ATP synthesis |
| ATP5F1D |
| ER protein translocation |
| SEC63 |
| Hippo signalling pathway |
| MOB1A |
| ER stress and unfolded protein response |
| ERMP1 |