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. 2021 Mar 11;12:652249. doi: 10.3389/fphar.2021.652249

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Copyright © 2021 Da, Tao, Wen, Tao, Wang and Zhu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Melatonin enhances the ZIP-1 expression in osteoblasts. (A) western blotting results of ZIP-1 (34 kDa), CTP (34 kDa), and β-actin (42 KDa) expression in different cell groups, (B) relative expression value of ZIP-1, (C) relative expression value of CTP, and (D) immunofluorescence results of ZIP-1 expression in different cell groups, the expression of ZIP-1 in OVX was significantly lower than that in sham group, and the melatonin treatment could significantly promote the expression of ZIP-1. *P-value < 0.05, **P-value < 0.01.