Table 5.

Predictive factors of toxicities of induction chemotherapy with TPF in patients treated for locally advanced head and neck cancer (multivariate analysis). Toxicity was assessed according to CTCAE classification V4.0

	Anemia	Neutropenia	Febrile neutropenia	Infection	Death
	Grade ≥ 3	Grade ≥ 3	Grade ≥ 3
Age	NS	NS	NS	NS	NS
Female sex	NS	NS	NS	NS	NS
Alcohol use	NS	NS	NS	NS	NS
Liver dysfunction	NS	NS	NS	NS	NS
Hepatic dysmorphia	NS	NS	NS	NS	NS
Prothrombin rate	0.049	NS	NS	NS	NS
Diabetes	NS	NS	NS	NS	NS
HBP	NS	NS	NS	NS	NS
Ischemic heart disease	NS	NS	NS	NS	NS
Obstructive pulmonary disease	NS	NS	NS	NS	NS
Obliterative arteriopathy of the lower limbs	NS	NS	NS	NS	NS
Performance status	NS	NS	NS	NS	NS
Weight loss before TPF	NS	NS	NS	NS	NS
Weight loss during TPF	NS	NS	NS	NS	NS
Enteral feeding during TPF	NS	NS	NS	0.047	NS