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. 2021 Mar 26;23(6):404. doi: 10.3892/mmr.2021.12043

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Copyright: © Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 7. — Nox4 overexpression reversed the inhibiting effects of TIIA on Ang II-induced fibrosis of CFs. Nox4 overexpression reversed the effects of TIIA in attenuating the increases of collagen I, collagen III, SMA, TGF-β, MMP2 and MMP9 in the Ang II-treated CFs. The results are expressed as mean ± standard error of the mean. *P<0.05 vs. the Ad-GFP group; #P<0.05 vs. the Ang II group; &P<0.05 vs. the Ang II + TIIA group. Nox, NADPH oxidase; TIIA, tanshinone IIA; Ang II, angiotensin II; CFs, cardiac fibroblasts; SMA, α-smooth muscle actin; MMP, matrix metalloproteinase.