Table 3.
DTI region of interest analysis
| Region of interest | Imaging metric | Control | 48 h | 1 Week | 4 Weeks | 10 Weeks | ANOVA (F) or |
|---|---|---|---|---|---|---|---|
| (Mean ± SEM) | Kruskal–Wallis (K) | ||||||
| Hippocampus | FA × 10–1 | 3.17 ± 0.108 | 3.74 ± 0.144* | 3.76 ± 0.174* | 3.04 ± 0.109# | 3.13 ± 0.0844# | F = 7.54; p < 0.0001 |
| MD × 10–3 | 1.04 ± 0.0227 | 1.02 ± 0.0261 | 1.02 ± 0.0340 | 0.984 ± 0.0277 | 1.11 ± 0.0422 | F = 2.16; p = 0.087 | |
| RD × 10–3 | 0.892 ± 0.0163 | 0.797 ± 0.0204 | 0.789 ± 0.0228† | 0.830 ± 0.0245† | 0.936 ± 0.0384# | F = 6.11; p = 0.0004 | |
| AD × 10–3 | 1.42 ± 0.0490 | 1.43 ± 0.0354 | 1.42 ± 0.0466 | 1.29 ± 0.0387 | 1.45 ± 0.0509 | F = 1.92; p = 0.12 | |
| Corpus Callosum | FA × 10–1 | 3.49 ± 0.0667 | 3.95 ± 0.0980* | 3.66 ± 0.147 | 3.43 ± 0.139# | 3.36 ± 0.0869# | F = 4.56; p = 0.003 |
| MD × 10–3 | 0.939 ± 0.0203 | 0.904 ± 0.0189 | 0.918 ± 0.0162 | 0.914 ± 0.0189 | 0.883 ± 0.0137 | F = 1.29; p = 0.28 | |
| RD × 10–3 | 0.762 ± 0.0169 | 0.689 ± 0.0763* | 0.739 ± 0.0125 | 0.746 ± 0.0158# | 0.726 ± 0.0135 | F = 4.24; p = 0.0048 | |
| AD × 10–3 | 1.29 ± 0.0302 | 1.30 ± 0.0322 | 1.26 ± 0.0353 | 1.25 ± 0.0325 | 1.22 ± 0.0288 | F = 1.07; p = 0.38 | |
Bold indicates statistically different according to the following key
SEM = standard error of the mean; * = significance from controls; # = significance from 48 h; † = significance from 10 weeks; FA = fractional anisotropy; MD = mean diffusivity; RD = radial diffusivity; AD = axial diffusivity