Table 1.
Clinical and laboratory characteristics of the overall population and stratified by CAD categories.
| Total (n) (N = 1625) |
No CAD (N = 504) | Subclinical CAD (N = 940) | Clinical CAD (N = 181) | p-value | |
|---|---|---|---|---|---|
| Clinical characteristics | |||||
| Age [IQR] (n) | 69 [58, 77] (1625) | 57 [50, 66] (504) | 72 [63, 79] (940) | 75 [69, 81] (181) | <0.001 |
| Male gender % (n) | 67.2 (1092) | 55.2 (276) | 70.9 (666) | 81.1 (150) | <0.001 |
| BMI [IQR] (n) | 26 [24 29] (560) | 26 [24, 29] (208) | 27 [24, 29] (297) | 26 [23, 28] (55) | 0.191 |
| Hypertension % (n) | 54.8 (885) | 34.3 (171) | 60.4 (565) | 82.3 (149) | <0.001 |
| Diabetes % (n) | 19.1 (309) | 7.8 (39) | 21.3 (199) | 39.2 (71) | <0.001 |
| Smoke % (n) | 6.5 (79) | 3.7 (15) | 6.8 (46) | 13.4 (18) | <0.001 |
| CKD % (n) | 7.3 (87) | 2.3 (9) | 7.2 (49) | 23.4 (29) | <0.001 |
| Atrial fibrillation % (n) | 9 (140) | 3.5 (17) | 10.1 (90) | 18.3 (33) | <0.001 |
| Peripheral artery disease %(n) | 6.1 (98) | 1.4 (7) | 6 (56) | 19.3 (35) | <0.001 |
| Chronic lung disease % (n) | 9.9 (160) | 5 (25) | 11.3 (106) | 16 (29) | <0.001 |
| Active malignancy % (n) | 5.1 (83) | 3 (15) | 5.9 (55) | 7.2 (13) | 0.009 |
| Laboratory data at admission | |||||
| Hb g/dl [IQR] (n) | 14 [12,15] (1617) | 14 [12, 15] (501) | 14 [12, 15] (936) | 13 [12, 15] (180) | 0.580 |
| WBC*103/mm3 [IQR] (n) | 6.8 [5.0, 9.9] (1548) | 6.2 [4.7, 9.2] (485) | 7.1 [5.3, 10.1] (884) | 7.3 [5.2, 10.6] (179) | <0.001 |
| Creat. Mg/dL [IQR] (n) | 1.0 [0.9, 1.2] (324) | 1.0 [0.8, 1.1] (115) | 1.0 [0.9, 1.2] (177) | 1.1 [1.0, 1,6] (32) | <0.001 |
| HS-TnI ng/L baseline [IQR] (n) | 10.9 [5.4, 32.9] (275) | 6.0 [2.7, 15.0] (91) | 10.9 [6.0, 35.5] (140) | 32.8 [14.8, 93.0] (44) | <0.001 |
| HS-TnI ng/L peak [IQR] (n) | 10.9 [5.4, 32.9] (265) | 9.9 [4, 31] (87) | 19.5 [9, 59.1] (140) | 53.1 [22.5, 150.1] (38) | <0.001 |
| LDH mg/dl [IQR] (n) | 354 [254, 480] (1140) | 330 [240, 442] (357) | 365 [264, 495] (665) | 350 [252, 463] (118) | 0.010 |
| CRP mg/L [IQR] (n)< | 11.5 [5.3, 20] (1594) | 10.5 [4.2,20.3] (486) | 10.9 [5.6, 20.1] (929) | 11.7 [6.6, 18.4] (179) | 0.070 |
BMI = body mass index, Creat. = creatinine, CKD = chronic kidney disease, CRP=C-reactive protein, Hb = haemoglobin, IQR = interquartile range, LDH = lactate dehydrogenase, HS-TnI = high-sensitivity troponin I, WBC = white blood cells.