Table 1.
Data summary
| Year | Author | Methodology | Population | Measure | Results | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Country | Recruitment setting | Sex (male, %) | Age (mean) | Genotype (SS, %) | Type | Name | Cut-off | N total | % depressed | ||
| 1999 | Wilson Schaeffer, J. J et al | USA | Outpatient | 43.86 | 33.70 | PA | CES-D 20 | 16 | 440 | 43.41 | |
| 2000 | Grant et al | USA | Outpatient | 41.86 | 35.02‡ | PA | CES-D 20 | 16 | 43 | 25.58 | |
| 2003 | Hasan et al | USA | Outpatient | 54.00 | 36.00 | 94.00 | PA | BDI-II | 14 | 50 | 44.00 |
| 2005 | Jenerette et al | USA | Cohort | 28.00 | 35.00 | PA | BDI 7 | 4 | 221 | 31.67 | |
| 2006 | Laurence et al | USA | Cohort | 43.54 | 79.40 | PA | CES-D 10 | 4 | 101 | 38.61 | |
| 2007 | Pells, J. et al | USA | Cohort | 36.82 | PA | LEMFPSCD (BDI-II) | 14 | 67 | 35.82 | ||
| 2008 | Levenson et al | USA | Cohort | 38.40 | 34.00 | 70.96 | PA | PHQ 9 | 10 | 232 | 27.59 |
| 2009 | Carroll et al | USA | Inpatient | 36.50‡ | 24.10‡ | MRR | n/a | 122 | 6.56 | ||
| 2009 | Edwards et al | USA | Outpatient | 36.82 | PA | LEMFPSCD (BDI-II) | 14 | 67 | 22.00 | ||
| 2010 | Anie et al | Nigeria | Outpatient | PA | PISCD | n/a | 253 | 44.27 | |||
| 2010 | Asnani et al | Jamaica | Cohort | 49.46 | 31.00 | PA | BDI-II | 14 | 277 | 21.66 | |
| 2010 | Kamble et al | USA | Outpatient | 42.96 | 34.20 | PA | BDI-II | 14 | 142 | 35.21 | |
| 2010 | Mahdi et al | Bahrain | Outpatient | 42.80 | 17.23‡ | 100 | PA | DASS 21 | 10 | 243 | 59.26 |
| 2011 | Carroll et al | USA | Inpatient | MRR | n/a | 1874 | 4.27 | ||||
| 2011 | Treadwell et al | USA | Outpatient | 31.20 | PA | PHQ 9 | 10 | 77 | 61.04 | ||
| 2012 | Rosine | Europe | Outpatient | 44.30 | 35.60 | 100† | PA | BDI-II | 14 | 89 | 49.44 |
| 2012 | Vilela et al | Brazil | Outpatient | 32.00 | 35.00 | 100 | PA | BDI-II | 20 | 24 | 16.67 |
| 2013 | Gibson et al | Jamaica | Outpatient | 48.00 | 36.40 | 70.00 | PA | BDI-II | 17 | 143 | 13.29 |
| 2014 | Morgan et al | Jamaica | Outpatient | 35.97 | 69.60 | PA | BDI-II | 14 | 140 | 15.00 | |
| 2014 | Wallen et al | USA | Cohort | 49.00 | 34.00 | 85.00† | PA | BDI-II | 16 | 315 | 20.63 |
| 2015 | Mann-Jiles et al | USA | Outpatient | 49.00 | 64.00 | MRR | n/a | 72 | 19.44 | ||
| 2015 | Mastandréa et al | Brazil | Outpatient | 38.20 | 30.00 | 72.70† | PA | PHQ 9 | 10 | 110 | 30.00 |
| 2015 | Treadwell et al | USA | Cohort | 40.00 | 31.60 | 73.00 | PA | PHQ 9 | 10 | 77 | 32.47 |
| 2016 | Al Sherawi et al | Oman | Outpatient Inpatient | 34.00 | PA | BDI-II | 14 | 123 | 39.02 | ||
| 2016 | Anim et al | Ghana | Outpatient | 51.00 | 65.00 | PA | BSI | ? | 201 | 0.00 | |
| 2016 | Fayand et al | Europe | Inpatient | 43.00 | 27.00 | MRR | n/a | 439 | 5.24 | ||
| 2016 | Ola et al | Nigeria | Outpatient | 38.83 | 25.30 | 98.06 | PA | PHQ 9 | 5 | 103 | 71.84 |
| 2016 | Master et al | USA | Outpatient | 48.00 | 33.00 | PA | PROMIS | 55 | 100 | 35.00 | |
| 2016 | Raji et al | Nigeria | Outpatient | 46.30 | 25.37 | Interview | Mini | n/a | 205 | 16.59 | |
| 2017 | Adam et al | USA | Outpatient | 28.00 | 35.40 | 56.00 | PA | BDI-II | 14 | 142 | 35.21 |
| 2017 | Dorociak et al | USA | Outpatient | 22.20 | 40.61 | PA | CES-D 20 | 16 | 54 | 38.89 | |
| 2018 | Alhomoud et al | Saudi Arabia | Outpatient | 57.30 | 31.70 | 100 | PA | BDI-II | 14 | 110 | 48.18 |
| 2018 | Alsubaie et al | Saudi Arabia | Outpatient | 35.90 | 26.40 | PA | HAM-D 17 | 8 | 78 | 85.90 | |
| 2018 | Ahmadi et al | Iran | Outpatient | 35.10 | 64.90 | PA | DASS 21 | 5 | 97 | 67.01 | |
| 2018 | Williams et al | USA | Inpatient | 52.00 | 27.50 | Interview | ED-Scan | n/a | 95 | 29.47 | |
| 2018 | Simo et al | USA | VOC | 20.00 | 80.00 | PA | PHQ 9 | 10 | 10 | 50.00 | |
CES-D Centre for Epidemiologic Studies-Depression, BDI Beck Depression Inventory, LEMFPSCD Longitudinal Exploration of Medical and Psychosocial Factors in SCD, PHQ Patient Health Questionnaire, DASS Depression Anxiety Stress Scale, BSI Brief Symptom Inventory, Mini Mini International Neuropsychiatric Interview, PROMIS Patient-Reported Outcomes Measurement Information System, HAM-D Hamilton Depression scale
(‡: estimated) (†: SS + Sβ°) (VOC vaso-occlusive crisis, PA psychometric assessment, MRR medical record review, SI structured interview)