Fig. 4.

Location of HIV-1 proviral integration sites identified by PCIP-seq in patients on cART. a HIV-1 proviral integration sites identified by PCIP-seq in two HIV-1 patients (02006 and 06042). Black lines represent integration sites where the portion of the provirus sequence shows no evidence of a large deletion, and red lines indicate sites where a large deletion was observed in the provirus. Detailed information for each HIV-1 integration site identified by PCIP-seq is available in Additional file 2. b A hotspot of proviral integration in intron 1 of STAT5B. Arrows represent individual proviruses (02006 = blue, 06042 = orange), and direction indicates the orientation of the provirus. All proviruses have the same transcriptional orientation as STAT5B