Fig. 6.
Binding of galidesivir with PLpro (NSP3). (A) The surface is colored as a function of electrostatic charge on the residues. The co-crystallized ligand (cyan sticks) and galidesivir (green sticks) (average docking score −11.90). (B) Superimposition of the snapshots and binding of galidesivir. (C) A close up of galidesivir-PLpro interactions. Hydrogen bonding interactions are shown for galidesivir (yellow sticks) and co-crystallized ligand (ADENOSINE-5-DIPHOSPHORIBOSE, cyan). The pink and blue dotted lines show hydrogen bonds galidesivir and co-crystallized ligand respectively. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)