Figure 1.

DBS in the MS alleviates seizure activities in KA‐induced acute seizure model. (A) Experiment scheme diagram of the KA‐induced seizure model and DBS modulation. DBS was delivered continuously after KA injection. (B‐F) The effects of DBS on the latency to the different seizure stage (B), seizure stage (C), incidence of SE (D), incidence of GS (E), and number of GS (F) during 1.5‐h observation period in KA‐induced acute seizure model. (n = 12 for each group. *P < 0.05, **P < 0.01, ***P < 0.001 compared with Sham group, non‐parametric Kruskal‐Wallis test followed by post hoc Dunn's tests was used for B, one‐way ANOVA followed by post hoc Dunnett tests was used for C and F, chi‐square test was used for D and E). (G‐H) Representative power spectrogram (G) and EEGs (H) recorded from the dorsal hippocampus. The arrows indicate the time of KA injection and the first onset time of seizure stage 2, 4, or 6