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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Hepatology. 2020 Oct 22;72(5):1586–1604. doi: 10.1002/hep.31167

Figure 2: Liver injury and hepatic and serum lipids in HF/HC-fed WT and ALR-deficient mice.

Figure 2:

Mice were fed chow or HF/HC diet for 16 weeks. (A) Liver of HF/HC-fed ALR-H-HET mouse looks paler than the WT mouse, while that of ALR-H-KO mouse is coarse. (B) Serum ALT, AST and ALP levels HF/HC-fed WT, ALR-H-HET and ALR-H-KO mice. (C) H/E-stained (10X magnification) liver sections showing much greater steatosis in HF/HC-fed ALR-H-HET compared to WT mice and very low steatosis in ALR-H-KO mice. (D) Hepatic triglycerides are strongly increased in HF/HC-fed WT and ALR-H-HET mice, and mildly in ALR-H-KO mice. (E) Hepatic cholesterol is significantly increased in HF/HC-fed ALR-H-HET but not WT or ALR-H-KO mice. (F) Serum triglycerides are elevated in HF/HC-fed WT and ALR-H-HET mice. (G) Serum cholesterol is mildly but significantly elevated in all groups of mice fed HF/HC diet.