Table 4.

Comparison of genotypic allocations of HBD-1 gene polymorphisms in smokers with entire controls at ages ≤ 29 years and ˃ 29 years

Polymorphisms	Alleles	Controls		≤ 29 years		OR	95% CI	X2	P value
		N	%	N	%
rs1047031	Total	171	100%	153	100%
	CC	141	83%	124	81%	Ref
	CT	28	16%	29	19%	1.178	0.664–2.088	0.31	0.57532
	TT	2	1%	0	0%	0.227	0.011–4.780	1.75	0.18621
	CT+TT	30	17%	29	19%	1.099	0.625–1.933	0.11	0.74261
	C	310	91%	277	91%	Ref
	T	32	9%	29	9%	1.014	0.598–1.720	0.00	0.95821
rs1799946	Total	175	100%	154	100%
	CC	52	30%	40	26%	Ref
	CT	83	47%	85	55%	1.331	0.798–2.220	1.21	0.27209
	TT	40	23%	29	19%	0.943	0.501–1.772	0.03	0.85410
	CT+TT	123	70%	114	74%	1.205	0.742–1.956	0.57	0.45070
	C	187	53%	165	54%	Ref
	T	163	47%	143	46%	0.994	0.731–1.352	0.00	0.97076
rs2738047	Total	176	100%	155	100%
	CC	170	97%	148	95%	Ref
	CT	6	3%	7	5%	1.340	0.441–4.076	0.27	0.60489
	TT	0	0%	0	0%	1.148	0.023–58.221	-	1.00000
	CT+TT	6	3%	7	5%	1.340	0.441–4.076	0.27	0.60489
	C	346	98%	303	98%	Ref
	T	6	2%	7	2%	1.332	0.443–4.007	0.26	0.60853
rs11362	Total	171	100%	155	100%
	CC	55	32%	47	30%	Ref
	CT	80	47%	85	55%	1.243	0.758–2.039	0.75	0.38795
	TT	36	21%	23	15%	0.748	0.389–1.435	0.77	0.38153
	CT+TT	116	68%	108	70%	1.090	0.681–1.742	0.13	0.72031
	C	190	56%	179	58%	Ref
	T	152	44%	131	42%	0.915	0.671–1.248	0.32	0.57376
Polymorphisms	Alleles	Controls		˃ 29 years		OR	95% CI	X2	P value
		N	%	N	%
rs1047031	Total	108	100%	130	100%
	CC	89	82%	115	88%	Ref
	CT	19	18%	14	11%	0.570	0.271–1.200	2.23	0.13553
	TT	0	0%	1	1%	2.325	0.094–57.747	0.77	0.37991
	CT+TT	19	18%	15	12%	0.611	0.294–1.270	1.77	0.18390
	C	197	91%	244	94%	Ref
	T	19	9%	16	6%	0.680	0.341–1.357	1.21	0.27147
rs1799946	Total	107	100%	131	100%
	CC	25	23%	34	26%	Ref
	CT	57	53%	63	48%	0.813	0.433–1.524	0.42	0.51752
	TT	25	24%	34	26%	1.000	0.482–2.076	0.00	1.00000
	CT+TT	82	77%	97	74%	0.870	0.480–1.576	0.21	0.64532
	C	107	50%	131	50%	Ref
	T	107	50%	131	50%	1.000	0.697–1.435	0.00	1.00000
rs2738047	Total	110	100%	131	100%
	CC	105	95%	126	96%	Ref
	CT	5	5%	5	4%	0.833	0.235–2.957	0.08	0.77754
	TT	0	0%	0	0%	0.834	0.016–42.390	-	1.00000
	CT+TT	5	5%	5	4%	0.833	0.235–2.957	0.08	0.77754
	C	215	98%	257	98%	Ref
	T	5	2%	5	2%	0.837	0.239–2.928	0.08	1.00003
rs11362	Total	109	100%	133	100%
	CC	37	34%	52	39%	Ref
	CT	57	52%	58	44%	0.724	0.414–1.265	1.29	0.25608
	TT	15	14%	23	17%	1.091	0.503–2.368	0.05	0.82563
	CT+TT	72	66%	81	61%	0.800	0.472–1.357	0.68	0.40819
	C	131	60%	162	61%	Ref
	T	87	40%	104	39%	0.967	0.670–1.394	0.03	0.85597

Abbreviations: HBD-1 = human beta-defensin-1, N = number, % = percent, Ref = reference allele, OR: odds ratio