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. Author manuscript; available in PMC: 2021 Apr 7.
Published in final edited form as: J Med Chem. 2019 Mar 29;62(7):3524–3538. doi: 10.1021/acs.jmedchem.8b02009

Scheme 1. Synthesis of Prodrugs 2 and 3a.

Scheme 1.

aReagents and conditions: (i) Boc-l-Lys(Ac)-OH, HBTU, DIEA, dichloromethane (DCM), 0 °C to room temperature (rt), 1.5 h, 79%; (ii) Fmoc-l-Lys(Ac)-OH, HBTU, DIEA, DCM, 0 °C to rt, 1.5 h, 67%.