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Stability of 6 in the presense of human recombinant enzymes. 6 was spiked in incubations containing no enzyme, cathepsin B, cathepsin L, a mixture of cathepsin B and L, or HDAC2, and prodrug disappearance was measured over a period of 3 h via LC–MS. 6 showed the highest rate of disappearance in the presense of combined cathepsin B and L. HDAC2 did not cause prodrug metabolism. Negative control without enzymes showed no metabolism, confirming 6 to be chemically stable.
