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. 2021 Mar 22;12:632236. doi: 10.3389/fphar.2021.632236

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Copyright © 2021 Xu, Wang, Yan, Zhu, Pan, Yang, Liu and Gong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nuciferine inhibited the expression of lipogenesis-related genes in fully differentiated adipocytes at different action times. 3T3-L1 preadipocytes were differentiated as described in “Method” section. On the ninth day following differentiation, the fully differentiated adipocytes were treated with 20 μM nuciferine for 24, 48, 72 and 96 h, then the total RNA was extracted and RT-qPCR were conducted to determine the mRNA levels of FAS (A), ACC (B), SREBP1 (C) and HSL (D). All of the results were normalized to the values of the internal control PPIA, and the results were expressed as fold changes of the Ct value relative to the control value, which was defined as 1. All results were presented as mean ± SE in three independent experiments. *p < 0.05 vs the control group (0 μM).