Table 1.

Inclusion and exclusion criteria

Inclusion criteria	Exclusion criteria
Woman aged > 18 years and < 70 years	Patients with previous history of heart disease or heart failure
First diagnosis of breast cancer at early stages (I, II, III)	Left ventricular dysfunction (left ventricular ejection fraction < 53%) at baseline
Patients who will receive adjuvant or neoadjuvant treatment with curative intention	Metastatic disease
Treatment with anthracyclines and/or anti-HER-2 antibodies (trastuzumab and pertuzumab)	Patients carrying an implantable cardioverter defibrillator
Possibility of completing a cardiac rehabilitation program and programmed visits	Patients with physical or mental limitation to carry out an exercise program
Providing written informed consent	Refuse to participate
	Overcome 20% of cardiotoxic treatment