Table 2.
Changes in systemic hemodynamic and microcirculatory parameters in septic patients before and after RIC during the study period
| I RIC at inclusion (n = 26) | II RIC after 12 h (n = 23) | III RIC after 24 h (n = 21) | ||||
|---|---|---|---|---|---|---|
| Before | After | Before | After | Before | After | |
| MAP, mmHg | 70 (62–78) | 74 (66–80) | 72 (69–80) | 73 (70–82) | 70 (64–76) | 71 (65–79) |
| HR, beats/min | 109 (84–121) | 108 (86–127) | 112 (81–126) | 106 (85–122) | 101 (77–115) | 92 (81–121) |
| CI, L/min m2 | 3.7 (2.8–4.3) | 3.9 (3.0–4.2) | 3.9 (3.3–5.3) | 4.2 (3.5–5.0) | 4.1 (3.5–5.2) | 4.1 (3.6–5.1) |
| Lactates, mmol/L | 1.4 (1.2–3.0) | 1.4 (1.1–4.4) | 1.3 (1.2–1.7) | 1.3 (1.1–2.0) | 1.4 (1.0–2.1) | 1.4 (0.9–2.5) |
| ScvO2, % | 77.6 (74.0–82.1) | 80.4 (71.9–83.3) | 81.1 (73.8–85.1) | 80.4 (72.3–84.7) | 73.8 (70.8–82.0) | 76.3 (69.3–81.8) |
| TVDs, mm/mm2 | 21.5 (19.1–25.1) | 21.8 (18.7–24.4) | 20 (17.8–25.8) | 20.6 (19.1–24.5) | 22.4 (18.8–24) | 22.8 (20.5–25.3) |
| PVDs, mm/mm2 | 18.9 (16.8–21.6) | 19.6 (17.1–21.8) | 18.6 (16.5–23.7) | 19.3 (17.5–21.0) | 19.6 (16.6–22.2) | 21.5 (18.6–22.4) |
| PPVs, % | 87.9 (82.4–93.8) | 92.5 (87.9–96.1)* | 91.3 (84.6–95.8) | 91.5 (86.4–95.4) | 90.6 (85.2–94.3) | 91.4 (86.5–95.8) |
| MFI | 2.17 (1.81–2.69) | 2.59 (2.21–2.83)* | 2.5 (2.00–2.83) | 2.58 (2.17–2.90) | 2.33 (2.17–2.67) | 2.50 (2.08–2.83) |
| DB, n/mm | 12.7 (10.7–14.2) | 12.2 (10.6–13.7) | 12.1 (10.2–14.7) | 11.6 (10.3–14) | 12.6 (11.4–13.8) | 12.8 (11.6–15.1) |
Data are presented as the median (interquartile range [IQR])
MAP mean arterial pressure, HR heart rate, CI cardiac index, TVDs total vascular density of small vessels, PVDs perfused small vessel density, PPVs proportion of perfused small vessels, MFI microcirculatory flow index, DB De Backer score, ScvO2 central venous oxygen saturation
*p < 0.05: significant difference before and after remote ischemic conditioning (RIC)