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. 2021 Feb 26;13(3):306. doi: 10.3390/pharmaceutics13030306

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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K562 cells after 15-min incubated with peroxidase-containing liposomes. (A) Cells still show a normal ultrastructure and one of them (top) appears in mitosis. (B) A liposome, in the form of a membrane-bound particle with electron-dense content, is attached to the plasma membrane (arrow and insert); to note that mitochondria show a normal appearance. (C) A liposome undergoing internalization by a coated pit (arrow and insert): the typical clathrin coating (arrowheads) is suggestive for a mechanism of receptor-mediated endocytosis. (D) A group of liposomes in proximity of a cell’s surface: some of them appear in the course of receptor-mediated endocytosis (arrowheads).