Figure 8.
Effects of pump inhibitors (free or liposomal TAR and TPGS) on DOXO cytotoxicity in K562/DOXO cells. In particular, data are reported for DOXO (A), DOXO plus TAR (B), DOXO plus TAR-L(C), DOXO plus TPGS (D), and DOXO+TPGS-L (E). Cytotoxic effects are expressed as the percentage of live, necrotic, and apoptotic cells detected in the samples incubated with DOXO in the presence and in the absence of the different pump inhibitors free and formulated.