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. Author manuscript; available in PMC: 2021 Apr 7.
Published in final edited form as: Anal Chem. 2020 Oct 22;92(21):14459–14465. doi: 10.1021/acs.analchem.0c02489

Figure 2.

Figure 2.

Comparison between single-cell MIP spectra and single-cell Raman spectra with the same spectral acquisition time of either 16, 4, or 1 s. (A,B) Single-cell spectrum of S. aureus showing SNR at different acquisition times using (A) MIP or (B) Raman microscopy. (C,D) Comparison of averaged spectra by (C) MIP and (D) Raman microscopy of untreated (darker) and erythromycin-treated (lighter) S. aureus at different acquisition times of 16 s (green), 4 s (orange), and 1 s (purple). The shaded area represents the standard deviation from single-cell measurements. (E,F) PCA of spectra of untreated and erythromycin-treated S. aureus cells at different acquisition times using (E) MIP and (F) Raman microscopy.