TABLE 1.

Role of HDAC in oocyte development and maturation.

Protein (gene)	Phenotype in vitro	Phenotype of KO	Phenotype of cKO	References
HDAC1	–	Embryo lethality between E9.5-E10.5	Hdac1ZP3–Cre: no phenotype	Leboeuf et al., 2010; Montgomery et al., 2007; Ma et al., 2012
			Hdac1/Hdac2ZP3–Cre: infertility due to oocyte development arresting at the secondary follicle stage
HDAC2	–	Embryonic and postnatal lethality	Hdac2ZP3–Cre: reduced fertility but the follicular development is normal
HDAC3	Knock down of Hdac3 in oocytes caused pindle/chromo some organization failure.	Embryonic death at or around the time of gastrulation	Hdac3Foxl2–ERT2–Cre: promotes the maturation of oocytes independent of LH	Bhaskara et al., 2008; Li et al., 2017; Wang et al., 2019
	Using HDAC3 inhibitor promotes the maturation of oocytes independent of LH
HDAC6	Inhibition by TubA: the maturational progression and meiotic apparatus assembly in mouse oocytes, and the oocytes failed to extrude the first polar body	Viable and fertile	–	Zhang et al., 2008; Bobrowska et al., 2011; Zhou et al., 2017; Sui et al., 2020a
HDAC8	knockdown by si-RNA or drug inhibition with its selective inhibitor PCI-34051: spindle defects and chromosome misalignment during oocyte meiotic maturation, accompanied by impaired kinetochore-microtubule attachments	Death within 4–6 h of birth from brain hemorrhaging	Hdac8Vasa–Cre: females were subfertile. Hdac8ZP3–Cre: oogenesis and folliculogenesis appeared normal and mice were fertile.	Zhang K. et al., 2017; Vijay Pratap et al., 2019
HDAC11	Inhibition of HDAC11 with its selective inhibitor JB3-22: interrupted mouse oocytes meiosis progress, abnormal spindle organization and misaligned chromosomes, impaired kinetochore-microtubule attachment and spindle assembly checkpoint function	Viable	–	Cheng et al., 2014; Sui et al., 2020b
SIRT1	Activation of SIRT1 by resveratrol in vitro improves oocyte quality and embryo development. Inhibition of SIRT1 results in increased ROS production and abnormal MII plates in mouse oocytes	Embryonic and fetal lethality	–	Liu et al., 2013; Di Emidio et al., 2014; Takeo et al., 2014; Wang et al., 2014; Itami et al., 2015; Li et al., 2016; Khan et al., 2017
SIRT2	Inhibitor and Knockdown: the progression of oocyte development was blocked	Viable	–	Zhang L. et al., 2014; Riepsamen et al., 2015
SIRT3	Overexpression of Sirt3 reduces the spindle defects and chromosome misalignment in oocytes	Viable	–	Lombard et al., 2007; Zhang L. et al., 2015
SIRT6	Depleted Sirt6 results in disruption of spindle morphology and chromosome alignment in oocytes	Postnatal lethality	–	Mostoslavsky et al., 2006; Han et al., 2015