eTable 6. Associations of baseline characteristics. study center and SARS-CoV-2 testing status with deterioration in self-rated health from baseline to time of COVID-NAKO questionnaire*^{1, 2}.

	OR	[95% CI]	p-value
Characteristics at baseline examination
Age. per 5 years	1.11	[1.10; 1.11]	< 0.001
Women	1,3	[1.25; 1.35]	< 0.001
Self-rated health. continuous	0,22	[0.21; 0.23]	< 0.001
Study center: reference Neubrandenburg
Leipzig	0,93	[0.83; 1.05]	0.25
Kiel	0,99	[0.88; 1.11]	0.84
Halle	0,99	[0.88; 1.11]	0.82
Essen	1	[0.89; 1.13]	0.97
Augsburg	0,91	[0.82; 1.00]	0.05
Mannheim	0,91	[0.81; 1.02]	0.10
Berlin	1,03	[0.95; 1.13]	0.46
Hanover	1,05	[0.93; 1.19]	0.39
Bremen	0,99	[0.89; 1.11]	0.90
Münster	0,99	[0.89; 1.11]	0.93
Düsseldorf	0,8	[0.70; 0.90]	< 0.001
Hamburg	0,84	[0.75; 0.95]	< 0.001
Saarbrücken	1,03	[0.92; 1.16]	0.58
Regensburg	0,95	[0.85; 1.07]	0.41
Freiburg	0,87	[0.78; 0.97]	0.01
SARS-CoV-2 test result: reference “not tested”
Negative test result	1,68	[1.54; 1.82]	< 0.001
Positive test result	2,38	[1.83; 3.10]	< 0.001

*¹ The parameters investigated were age. sex. self-rated health status at baseline examination. study center. and SARS-CoV-2 test status.

*² Results from a logistic regression model with the dichotomous outcome: “self-rated health status at the time of the COVID-NAKO questionnaire is worse than at the baseline examination”. Self-rated health at the baseline examination was regarded in the model as continuous. with 1 meaning “excellent” and _5 signifying “poor”.

OR. Odds ratio; CI. confidence interval