Table 2. Diagnostic accuracy of 2D SWE and VCTE for the diagnosis of fibrosis stage.

	≥F1 (95% CI)		≥F2 (95% CI)		≥F3 (95% CI)		F4 (95% CI)
	2D SWE	VCTE	2D SWE	VCTE	2D SWE	VCTE	2D SWE	VCTE
AUROC	0.815 (0.760–0.869)	0.777 (0.689–0.875)	0.870 (0.823–0.917)	0.837 (0.789–0.925)	0.910 (0.872–0.948)	0.897 (0.805–0.968)	0.933 (0.892–0.974)	0.923 (0.863–0.987)
Cut-off value	6.430	7.672	7.250	9.921	8.409	11.892	10.047	14.864
Sensitivity	0.832 (0.758–0.887)	0.595 (0.510–0.675)	0.874 (0.785–0.929)	0.649 (0.564–0.725)	0.875 (0.760–0.940)	0.893 (0.781–0.953)	0.889 (0.709–0.968)	0.926 (0.753–0.989)
Specificity	0.659 (0.557–0.748)	0.791 (0.696–0.862)	0.689 (0.606–0.761)	0.747 (0.648–0.825)	0.759 (0.688–0.818)	0.745 (0.663–0.796)	0.826 (0.766–0.873)	0.734 (0.678–0.800)
PPV	0.779 (0.710–0.847)	0.804 (0.725–0.883)	0.644 (0.558–0.730)	0.787 (0.710–0.864)	0.551 (0.447–0.654)	0.532 (0.431–0.633)	0.414 (0.287–0.541)	0.333 (0.227–0.440)
NPV	0.732 (0.636–0.828)	0.576 (0.489–0.663)	0.894 (0.835–0.953)	0.596 (0.506–0.687)	0.947 (0.909–0.985)	0.953 (0.917–0.990)	0.982 (0.961–1.000)	0.986 (0.968–1.000)
LR+	2.443 (1.817–3.284)	2.852 (1.866–4.358)	2.808 (2.158–3.654)	2.567 (1.764–3.736)	3.631 (2.724–4.841)	3.369 (2.574–4.409)	5.098 (3.653–7.114)	3.611 (2.779–4.692)
LR–	0.255 (0.169–0.383)	0.511 (0.405–0.646)	0.184 (0.104–0.323)	0.470 (0.362–0.610)	0.165 (0.082–0.331)	0.146 (0.068–0.312)	0.135 (0.046–0.392)	0.112 (0.026–0.379)

2D SWE, two-dimensional shear wave elastography; AUROC, area under the receiver operating characteristic curve; CI: confidence interval; LR+, positive likelihood ratio; LR−, negative likelihood ratio; NPV, negative predictive value; PPV, positive predictive value; VCTE, vibration controlled transient elastography.