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. 2021 Apr 7;16(4):e0249493. doi: 10.1371/journal.pone.0249493

Table 3. Diagnostic accuracy of UGAP and CAP for the diagnosis of steatosis grade.

≥S1 (95% CI) ≥S2 (95% CI) S3 (95% CI)
UGAP CAP UGAP CAP UGAP CAP
AUROC 0.891 * (0.837–0.945) 0.829 (0.775–0.903) 0.909 * (0.869–0.949) 0.832 (0.782–0.902) 0.924 ** (0.877–0.972) 0.801 (0.717–0.886)
Cut-off value 0.493 241 0.654 276 0.691 300
Sensitivity 0.791 (0.729–0.842) 0.627 (0.558–0.691) 0.842 (0.723–0.916) 0.807 (0.684–0.890) 0.882 (0.642–0.977) 0.765 (0.521–0.908)
Specificity 0.900 (0.684–0.982) 0.950 (0.743–1.000) 0.866 (0.804–0.910) 0.774 (0.704–0.832) 0.833 (0.776–0.878) 0.721 (0.655–0.778)
PPV 0.988 (0.970–1.000) 0.992 (0.977–1.000) 0.686 (0.577–0.794) 0.554 (0.447–0.661) 0.306 (0.177–0.435) 0.186 (0.095–0.277)
NPV 0.300 (0.184–0.416) 0.202 (0.121–0.283) 0.940 (0.903–0.978) 0.920 (0.875–0.965) 0.988 (0.972–1.000) 0.974 (0.948–0.999)
LR+ 7.910 (2.120–29.515) 12.537 (1.850–84.946) 6.278 (4.188–9.410) 3.577 (2.622–4.880) 5.294 (3.721–7.532) 2.737 (1.941–3.859)
LR- 0.232 (0.171–0.315) 0.393 (0.320–0.482) 0.182 (0.100–0.333) 0.249 (0.146–0.426) 0.141 (0.038–0.520) 0.327 (0.138–0.773)

AUROC, area under receiver the operating curve; CAP, controlled attenuation parameter; CI: Confidence interval; LR+, positive likelihood ratio; LR–, negative likelihood ratio; NPV, negative predictive value; PPV, positive predictive value; UGAP, ultrasound-guided attenuation parameter.

* p < 0.05 (compared with CAP).

** p < 0.01 (compared with CAP).