Fig 1. Conservation gradient induced from a protein residue is linearly correlated with its conservation within the protein.

(A) Violin plots and respective average of conservation gradient from a residue as a function of conservation rank for all residues in the dataset binned into 20 equally spaced bins of conservation rank along with the linear fit calculated over all residues. (B) Distribution of per-protein Pearson correlation between residues’ conservation ranks and conservation gradients.