Table 1. Average side-chain weighted contact number (SC-WCN) and distance to the protein center as well as average conservation gradient of the different types of functional sites.
| Functional sites | Mean SC-WCN | Mean distance to protein center | Mean conservation gradient |
|---|---|---|---|
| Catalytic sites | 2.62±0.03 | 7.1±0.4 | 0.41±0.01 |
| Non-catalytic ligand binding sites in enzymes | 2.65±0.03 | 9.3±0.4 | 0.30±0.01 |
| Ligand binding sites in nonenzymes | 1.92±0.02 | 7.4±0.3 | 0.37±0.01 |
| Protein-protein interaction sites | 1.70±0.01 | 14.8±0.1 | 0.21±0.00 |
| Allosteric sites | 2.03±0.01 | 10.8±0.2 | 0.24±0.00 |
| Buried non-functional sites# | 3.32±0.00a | 2.5±0.00b | 0.24±0.00a 0.20±0.00b |
# chosen as either
a sites for which SC-WCN>3.0
b sites for which distance to the protein center is <5.0