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. Author manuscript; available in PMC: 2021 Apr 7.
Published in final edited form as: Mutat Res. 2019 Apr 25;815:30–40. doi: 10.1016/j.mrfmmm.2019.04.002

Table 1.

Function and tissue distribution of genes flanking the GDKN2A locus.

Telomere proximal genes
 Centromere proximal genes
Gene Name Function Tissue specificity Gene Name Function Tissue specificity
SLC24A2 Calcium/Cation Antiporter Brain ELAVL2 Neural-specific RNA binding protein, metalloprotease stabilization Brain
MLLT3 Superelongation complex subunit, Mixed Lineage Leukemia family Ubiquitous TUSC 1 Tumor supressor, possible role in lung tumors N/A
FOCAD Focal adehesion protein, tumor supressor function in gliomas Ubiquitous CAAP 1 Apoptosis Inhibitor Ubiquitous
MIR31HG Small non-coding RNA Cellclar pluripotency and differentiation Digestive system Urinary System Brain TEK Receptor Tyrosine Kinase Ubiquitous
IFN Proteins released by host cells in response to pathogens Secreted MOB3B Mps 1 inter actor, mitotic checkpoint regulation Ubiquitous Highest in lung
MTAP Polyamine metabolism, adenine and methionine salvage Ubiquitous LING02 Leucine rich repeat and Ig domain, associated with Parkinson’s disease High in brain, endometrium, testis, thyroid