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. 2021 Apr 7;7(15):eabe9274. doi: 10.1126/sciadv.abe9274

Fig. 7. GAT2 deficiency attenuates HFD-induced obesity in mice.

Fig. 7

(A) GAT2 deficiency slows the increase of body weight of HFD-fed mice (n = 10 to 12). BW, body weight. (B) GAT2 deficiency reduces the weight of liver and adipose tissues of HFD-fed mice (n = 10 to 12). (C) The levels of IL-1β and TNF-α in adipose tissues (n = 10 to 12). (D) The expressions of F4/80 in adipose tissues of mice were determined by immunohistochemistry (400×) (n = 6). Data are shown as means ± SEM. (E) Immunofluorescence analysis of adipose tissues (400×), immunostained for iNOS (red) and CD206 (green). Scale bars, 100 μm (n = 6). Data were analyzed by unpaired t test and represented as means ± SD unless indicated. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001.