Figure 1.

Age-Standardized Prevalence Ratios of Hypertension by PRS Deciles

For survivors in the CCSS original and expanded cohorts (self-report of hypertension) and the SJLIFE study (clinical assessment of hypertension), the ratio of the observed number of hypertensive survivors in each individual cohort to the expected number was calculated. The nonparametric bootstrap with 1,000 replicates was used to estimate the 95% confidence interval. Among survivors with the PRS in the top decile, the prevalence of hypertension was greater than expected in all 3 cohorts. CCSS = Childhood Cancer Survivor Study; PRS = polygenic risk score; SJLIFE = The St. Jude Lifetime Cohort.