Table 2.

Multivariable Adjusted Associations of the Blood Pressure PRS From the General Population With Hypertension Among Childhood Cancer Survivors

PRS	CCSS Original Cohort (790 Hypertensive Survivors; 2,782 Hypertension-Free Survivors)			CCSS Expansion Cohort (160 Hypertensive Survivors; 1,729 Hypertension-Free Survivors)			SJLIFE (728 Hypertensive Survivors; 1,806 Hypertension-Free Survivors)			Combined Sample (1,678 Hypertensive Survivors; 6,317 Hypertension-Free Survivors)
	OR (95% CI)	p Value	C-Index	OR (95% CI)	p Value	C-Index	OR (95% CI)	p Value	C-Index	OR (95% CI)	p Value	C-Index
Per SD change	1.31 (1.20–1.42)	<0.001	0.736	1.33 (1.12–1.58)	<0.001	0.747	1.39 (1.26–1.54)	<0.001	0.788	1.34 (1.26–1.43)	<0.001	0.785
1st decile	Ref.
2th–5th deciles	1.17 (0.85–1.62)	0.329	0.736	1.83 (0.93–3.63)	0.082	0.745	1.18 (0.81–1.73)	0.385	0.787	1.24 (0.99–1.56)	0.066	0.784
6th–8th deciles	1.44 (1.04–2.00)	0.030		1.89 (0.95–3.77)	0.072		1.76 (1.20–2.58)	0.004		1.61 (1.27–2.03)	<0.001
9th decile	1.89 (1.29–2.79)	0.001		2.29 (1.03–5.10)	0.042		2.32 (1.46–3.70)	<0.001		2.08 (1.58–2.75)	<0.001
10th decile	2.63 (1.80–3.83)	<0.001		3.03 (1.39–6.60)	0.005		2.60 (1.66–4.06)	<0.001		2.66 (2.03–3.48)	<0.001

Covariates included age at childhood cancer diagnosis, age at last follow-up, sex, body mass index, smoking status (current or former vs. never), physical activity (vigorous intensity exercise in metabolic equivalents), cohort (CCSS original cohort, CCSS expansion cohort, and SJLIFE), alkylating agents, heavy metals, abdominal radiation, hypothalamic-pituitary axis radiation, total body radiation, and nephrectomy.

CI = confidence interval; OR = odds ratio; PRS = polygenic risk score derived from 895 blood pressure loci in Evangelou et al. (13); other abbreviations as in Table 1.