Table 1.
Most similar canonical pathways, GO terms and TXG-MAP modules compared to the six gene expression biomarkers
| Biomarker | Most similar gene set | Pearson R1 |
|---|---|---|
| Canonical pathways / GO terms | ||
| Cytotox biomarker | GO cellular response to hydrogen peroxide | 0.71 |
| AhR Biomarker | REACTOME Genes involved in Xenobiotics | 0.48 |
| CAR Biomarker | KEGG Glutathione metabolism | 0.75 |
| ER Biomarker | BIOCARTA Nuclear Receptors in Lipid Metabolism and Toxicity | 0.44 |
| Genotoxicity Biomarker | BIOCARTA p53 Signaling Pathway | 0.56 |
| PPARα Biomarker | GO fatty acid catabolic process | 0.94 |
| TXG MAP modules (enriched GO term) | ||
| Cytotox biomarker | Module 18m (cell adhesion) | 0.64 |
| AhR Biomarker | Module 108 (insulin secretion) | 0.50 |
| CAR Biomarker | Module 42m (glutathione metabolic process) | 0.71 |
| ER Biomarker | Module 206 (prostate gland development) | 0.53 |
| Genotoxicity Biomarker | Module 205 (cellular response to DNA damage) | 0.69 |
| PPARα Biomarker | Module 17m (fatty acid metabolic process) | 0.82 |
1
Pearson R obtained by comparing biomarker scores for 3528 treatments from TG-GATEs (compound, dose and time) vs. the most similar canonical pathway / GO term or TXG-MAP module, as obtained from the CTox application (Sutherland, et al., 2019a).