Table 3.
Specificity in testing of clinical samples without SARS-CoV-2
| Number of samples | Abbott | RapiGEN | Healgen | Coris BioConcept | R-Biopharm | nal von minden | Roche-SD Biosensor | ||
|---|---|---|---|---|---|---|---|---|---|
| Pathogen | |||||||||
| Adenovirus | 9 | 0 | 0 | 1* | 0 | 0 | 0 | 0 | |
| Bocavirus | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| HCoV-NL63 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| HCoV-OC43 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Enterovirus or rhinovirus | 9 | 0 | 0 | 1* | 0 | 0 | 0 | 0 | |
| Influenza virus A H1 | 10 | 0 | 0 | 2* | 0 | 1† | 0 | 0 | |
| Influenza virus A H3 | 9 | 0 | 0 | 2‡ | 0 | 1† | 0 | 0 | |
| Influenza virus B | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Metapneumovirus | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| HPIV-1 | 8 | 0 | 0 | 3* | 0 | 0 | 0 | 0 | |
| HPIV-2 | 3 | 0 | 0 | 2‡ | 0 | 0 | 0 | 0 | |
| HPIV-3 | 10 | 0 | 0 | 1*§ | 0 | 0 | 0 | 1†§ | |
| RSV-A | 7 | 1* | 0 | 0 | 0 | 0 | 0 | 0 | |
| RSV-B | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Mycoplasma pneumoniae | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Legionella pneumophila | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Total | 100 | 1 | 0 | 12 | 0 | 2 | 0 | 1 | |
Data indicate the number of SARS-CoV-2 false-positive results for each antigen point-of-care test. HCoV=human coronavirus. HPIV=human parainfluenza virus. RSV=respiratory syncytial virus.
*
Non-specific positive reaction was reproduced in a repeat test for the false-positive sample or samples.
†
Non-specific positive reaction was not reproduced in a repeat test.
‡
Non-specific positive reaction was reproduced in a repeat test for one of the two false-positive samples (reaction not reproduced for the other false-positive sample).
§
The same sample tested positive in the Healgen and Roche-SD Biosensor assays.