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Inhibition (a) and dose-dependent inhibition (b) of Ebselen and Ebsulfur on Mpro in the presence and absence of DTT. The Mpro (0.2 μM) was incubated with the compounds in the absence and presence of DTT (4 mM) buffer for 30 min. The enzymatic reaction was initiated by the addition of 20 μM substrate and the initial rate was determined. The reaction buffer without inhibitor (0.5% DMSO) was used as control.
