(a) Abundance distribution of quantified N-sialoglycosylation sites between MCF7 and MDA-MB-231 cells. (b) Protein clustering of up-regulated N-sialoglycoproteins based on biological processes. (c) Domain analysis of up-regulated N-sialoglycoproteins.
Adapted with permission from Chen, W., Smeekens, J. M., & Wu, R. (2015). Systematic and site-specific analysis of N-sialoglycosylated proteins on the cell surface by integrating click chemistry and MS-based proteomics. Chemical Science, 6(8), 4681–4689. Copyright by the Royal Society of Chemistry.