Table 2.
Linear association of thyroid status (TSH and FT4) with cardiovascular function during hospitalization.
| TSH (μIU/mL) | FT4 (ng/dL) | |||
|---|---|---|---|---|
| β (95% CI) | p value | β (95% CI) | p value | |
| Heart rate, bpm | ||||
| Unadjusted | −1.04 (−4.38 to 2.30) | 0.539 | 9.44 (−4.29 to 23.18) | 0.177 |
| Model 1a | −1.25 (−4.61 to 2.11) | 0.465 | 9.16 (−4.71 to 23.03) | 0.194 |
|
| ||||
| Blood pressure | ||||
| Systolic BP, mmHg | ||||
| Unadjusted | 2.15 (−1.71 to 6.01) | 0.274 | −9.97 (−25.42 to 5.48) | 0.205 |
| Model 1a | 1.88 (−1.95 to 5.72) | 0.334 | −8.51 (−24.03 to 7.01) | 0.281 |
| Diastolic BP, mmHg | ||||
| Unadjusted | 2.74 (0.34 to 5.13) | 0.025 | −3.24 (−13.13 to 6.66) | 0.519 |
| Model 1a | 2.68 (0.27 to 5.09) | 0.030 | −3.01 (−13.01 to 7.00) | 0.554 |
| BNP, pg/mL | ||||
| Unadjusted model | 0.02 (−0.12 to 0.15) | 0.828 | 0.28 (−0.26 to 0.82) | 0.305 |
| Model 1a | 0.05 (−0.08 to 0.19) | 0.439 | 0.19 (−0.34 to 0.72) | 0.478 |
|
| ||||
| Echocardiographic measures | ||||
| LV ejection fraction, % | ||||
| Unadjusted model | −2.16 (−7.30 to 2.98) | 0.401 | −29.05 (−52.24 to −5.85) | 0.016 |
| Model 1a | −1.13 (−6.08 to 3.83) | 0.649 | −24.85 (−47.87 to −1.82) | 0.035 |
| PASP, mmHg | ||||
| Unadjusted model | −0.45 (−4.59 to 3.70) | 0.830 | 12.77 (−4.74 to 30.28) | 0.150 |
| Model 1a | −0.56 (−4.81 to 3.70) | 0.795 | 13.27 (−4.45 to 31.00) | 0.140 |
The values shown are linear regression coefficients (β) and 95% confidence intervals, estimated by uni- and multivariate linear regressions, with TSH or FT4 as the independent variable and heart rate, systolic BP, diastolic BP, BNP, LV ejection fraction, and PASP as dependent variables. TSH and BNP were log-transformed. TSH: thyroid-stimulating hormone; FT4: free thyroxine; CI: confidence interval; BP: blood pressure; BNP: B-type natriuretic peptide; LV: left ventricle; PASP: pulmonary arterial systolic pressure. aAdjusted for age and sex.