Figure 2.

(a) Ileocolic high-grade MiNEN showing both the adenocarcinoma (mucinous glands at the bottom left) and neuroendocrine carcinoma (numerous solid irregular cords and nests, without lumen or mucin production) components. (b) High-power field of the neuroendocrine carcinoma: irregular nuclei with hyperchromasia, high nuclear/cytoplasmic ratio, no prominent nucleoli, and abundant mitotic figures. (c) Ki-67 immunostain shows a very high proliferating index (about 80%) in a NEC metastatic lymph node. (d) Strong and diffuse synaptophysin positivity in a lymph node sample, correspondent with NEC.