Table 2.
The IC50 values of hydroxyxanthone derivatives on Plasmodium falciparum 3D-7 and FCR-3 after 72 hours incubation period using microscopic method.
| Compound | Structure | IC50 (μM) on P. falciparum 3D-7 | IC50 (μM) on P. falciparum FCR-3 |
|---|---|---|---|
| 1,6,8-Trihydroxyxanthone (HX1) |
|
6.10 ± 2.01 | 6.76 ± 2.38 |
| 1,6-Dihydroxyxanthone (HX2) |
|
71.78 ± 0.31 | 81.77 ± 5.78 |
| 1,5,6-Trihydroxyxanthone (HX3) |
|
27.64 ± 0.19 | 64.09 ± 5.08 |
| 1-Hydroxy-5-chloroxanthone (HX4) |
|
85,30 ± 0.87 | 89.85 ± 7.69 |
| 1,6-Dihydroxy-5-methylxanthone (HX5) |
|
46.69 ± 0.29 | 59.73 ± 0.78 |
| Chloroquine |
|
0.01 ± 0.001 | 0.11 ± 0.052 |