Table 1.

Spatial coordinates of the local maxima in the hippocampus and RSC/POS ROIs in the fMRI analyses on age-related differences in neural activation patterns (p < 0.05, FWE-corrected)

Brain region	Cluster size	MNI coordinate			Z-score
		x	y	z
Increased activity in older compared with younger adults during navigation vs control
L POS	83	−3	−60	34	4.56
L RSC		−6	−57	21	4.32
L Hippocampus	72	−21	−18	−12	4.76
		−30	−15	−22	4.21
Reduced activity in older compared with younger adults during navigation vs control
R POS	22	12	−69	54	4.00
		18	−69	57	3.94
		15	−75	51	3.25
R POS	55	27	−60	24	3.96
Increased activity in older compared with younger adults during retrieval vs encoding
R POS	27	12	−51	34	4.03
L Hippocampus	33	−30	−15	−15	4.08
R Hippocampus	20	24	−12	−12	3.97
Age-group differences in learning-related activity decreases
R Hippocampus	20	24	−18	−15	4.55
Age-group differences in learning-related activity increases
L POS	462	−9	−66	24	5.93
		−24	−72	47	5.37
L RSC		−18	−57	1	4.14
		−6	−63	11	3.98
R POS	148	24	−69	47	4.95
		21	−72	54	4.73
R RSC	205	9	−57	4	4.82
		9	−63	21	4.59

See Extended Data Table 1-1 for significantly activated clusters elsewhere in the brain.