Figure 4.

Trans-synaptic regulation of gene expression: transmitter release and synapse remodeling, and a late shift to proteostasis and neuroprotection. A, Experimental design. B, Enrichment of GO biological process terms in third antennal segment transcriptomes after 12, 48, and 96 h induction of Kir2.1. The dendrogram represents semantic groupings among GO terms. C, Expression levels of transcripts attached to two semantic groupings, “transmitter release” and “synapse remodeling” (B), after 12 h of induction of Kir2.1 or Kir2.1-nc. Each column represents a sequencing library. Red type indicates gene products previously implicated in homeostatic synaptic plasticity (see Discussion).